申请结题学生：常栋彪

参加会议： TERMIS-AP 2026

会议时间：2026.10.27-30

会议地点： 新西兰 基督城

学术报告时间：2026年11月7日 9:00

学术报告地点：九里校区工业园A204

学术报告题目：

Regulating the Structure and Performance of Hydroxyapatite via Hydroxycarboxylic Acids

学术报告摘要：

Biomineralization is a natural process in which organic components guide the nucleation, growth, and assembly of inorganic minerals, ultimately yielding organic–inorganic composites with hierarchical architectures and excellent properties. This process is particularly instructive for calcium phosphate (CaP) formation in living organisms and the development of hard tissues. Inspired by biomineralization, organic molecules have attracted extensive interest as additives for synthesizing inorganic materials with tunable size and morphology. In this work, we selected several carboxylic acids bearing different numbers of carboxyl and hydroxyl groups as additives to investigate their effects on the morphology and structural characteristics of hydroxyapatite (HAp). Molecular dynamics simulations were employed to elucidate the underlying mechanisms by which hydroxycarboxylic acids modulate HAp crystallization. Notably, as the number of carboxyl or hydroxyl groups increased, the resulting HAp exhibited a decreasing particle size (from ~45 μm to ~2 μm) and an increasing specific surface area. The functional groups coordinate with calcium ions, weakening the interaction between Ca species and phosphate ions, thereby suppressing CaP nucleation and growth. Furthermore, the magnesium-ion–enhanced hydroxyapatite/hyaluronic acid composite (HA/MgHAp), regulated by malic acid, was developed as a bioenergetically active filler for rejuvenating aged skin. Such fillers can effectively reverse fibroblast senescence by promoting mitochondrial metabolic reprogramming. Meanwhile, they attenuate senescence-associated secretory phenotypes (SASP) and activate the TGF-β/SMAD signaling pathway, thereby facilitating extracellular matrix remodeling. As a dual regulator of mitochondrial metabolism and the regenerative microenvironment, the HA/MgHAp composite provides a bioenergetically active strategy for next-generation soft-tissue fillers aimed at rejuvenating aged tissues. Overall, this study highlights the critical roles of carboxyl and hydroxyl moieties in calcium phosphate mineralization and offers new directions for their application in tissue engineering.